Research advances in the association between the adenosine triphosphate-binding cassette transporter A1 geneand coronary heart disease

VernacularTitle:人三磷酸腺苷结合盒转运蛋白A1基因与冠心病关系的研究进展
Author: Zhi LUO ¹ ; Zhan LYU ; Yongyan SONG
Author Information

1. 川北医学院附属医院心内科
Keywords: Carrier proteins; Polymorphism; single nucleotide; Coronary heart disease
From: Chinese Journal of Geriatrics 2018;37(9):1051-1054
CountryChina
Language:Chinese
Abstract: The human adenosine triphosphate-binding cassette transporter A1(ABCA1)gene is highly polymorphic.Some polymorphisms in promoters (rs2422493 ,rs2740483 ,etc. ) and exons (rs2230806 ,rs4149313 ,etc. )have been reported to be significantly associated with coronary heart disease(CHD ). In terms of the underlying mechanisms ,ABCA1 gene polymorphisms might be associated with CHD through modulating the levels of high-density lipoprotein cholesterol and other lipids ,or through changing ABCA1 protein structure and function. In this article ,the association of ABCA1 gene polymorphisms with CHD and the underlying mechanisms are reviewed.