Effects of a high loading dose of Rosuvastatin on the prevention of contrast-induced nephropathy in high-risk patients
10.3760/cma.j.issn.0254-9026.2018.09.005
- VernacularTitle:负荷剂量瑞舒伐他汀钙对老年高危患者对比剂肾病发生的影响
- Author:
Chuanrong LI
1
;
Changqing LIU
;
Gaopin HU
;
Zhijian LIU
;
Meiying FEI
;
Fei SUN
Author Information
1. 116021,大连医科大学解放军第210医院研究生培训基地
- Keywords:
Rosuvastatin;
Diabetes mellitus;
Contrast-induced nephropathy
- From:
Chinese Journal of Geriatrics
2018;37(9):974-977
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the preventive effect of a high loading dose of Rosuvastatin on contrast-induced nephropathy (CIN )after PCI in high-risk patients. Methods A total of 199 patients with diabetes mellitus and chronic kidney disease (CKD)(45< GFR<90 ml · min-1 · 1.73 m -2 )scheduled for PCI were included and randomized into two groups ,one group receiving a high loading dose of rosuvastatin(20 mg Rosuvastatin in 3 days before and after PCI ,Rosuvastatin Group-RG)and the other one (Control-Group-CG)receiving 10 mg/d Rosuvastatin.Serum samples were collected at baseline ,48 and 72 hours after PCI for testing of creatinine ,C-reactive protein (CRP ) , interleukin-6(IL-6) ,and malondialdehyde(MDA). Results Post-PCI levels of CRP ,IL-6 ,and MDA in the RG were significantly lower than in the CG [(10.44 ± 3.82 )mg/L vs. (12.62 ± 3.68) mg/L , (14.66 ± 3.61 )ng/L vs. (16.41 ± 4.73 )ng/L ,(7.2 ± 2.2) mmol/L vs. (8.6 ± 1.5) mmol/L ,P=0.000 ,0.004 ,and 0.000 ,respectively].The levels of creatinine after PCI in both groups were found to be higher than baseline levels ,while the increase in the RG was smaller than in the CG [(10 ± 10)μmol/L vs. (15 ± 15)μmol/L ,P=0.007]. The incidence of CIN in the RG was lower than in the CG (8.2％ vs.19.8％ ,χ2 = 5.573 ,P= 0.018). Conclusions High-dose Rosuvastatin treatment can reduce the incidence of CIN in high-risk patients undergoing PCI.
