Association between rs579459 polymorphism of ABO gene and clinical severity of coronary heart disease in Chinese Han population

VernacularTitle:ABO基因多态性rs579459与中国汉族人冠心病严重程度的相关性研究
Author: Min GAO ¹ ; Wensheng LU ; Muqiu WANG
Author Information

1. 230001,中国科学技术大学附属第一医院安徽省立医院心电科
Keywords: Coronary disease; Polymorphism; single nucleotide; ABO gene
From: Chinese Journal of Geriatrics 2018;37(9):971-973
CountryChina
Language:Chinese
Abstract: Objective To investigate the association of rs579459 polymorphism in ABO gene with clinical severity of coronary heart disease (CHD) in Chinese Han population. Methods Based on the results of study on the association with CHD conducted by our team ,the rs579459 polymorphism in ABO gene and clinical data of 515 Chinese Han patients with CHD and 908 healthy individuals were collected and analyzed with Plink 1.07 software. Results The rs579459 polymorphism in ABO gene using allele model showed a statistically significant difference between CHD and control group (OR :1.28 ,95％ CI :1.11-1.65 ;P=0.027).When stratified by the severity of CHD ,the rs579459 polymorphism in ABO gene using allele model showed statistically significant difference between the severe CHD group and control group (OR :1.78 ,95％ CI :1.25-2.34 ;P=1.85 × 10-4 ). Conclusions The rs579459 polymorphism of ABO gene is associated with susceptibility to CHD in Chinese Han population ,and also with the severity of CHD.