Effect of ultrafiltration on the renal function in the treatment of patients with acute heart failure: A meta-analysis
10.3760/cma.j.issn.0254-9026.2018.07.023
- VernacularTitle:超滤治疗对急性心力衰竭患者肾功能影响的荟萃分析
- Author:
Qiukuan SHI
1
;
Peng LI
;
Pulin YU
Author Information
1. 100730,北京医院国家老年医学中心期刊编辑部
- Keywords:
Ultrafiltration;
Heart failure;
Renal insufficiency
- From:
Chinese Journal of Geriatrics
2018;37(7):821-825
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of uhrafiltration on the renal function in the treatment of patients with acute heart failure.Methods We retrieved as high a proportion as possible of relevant randomized controlled trials (RCT) from PubMed,EMBASE,Cochrane Library,Cochrane clinic test center registration bank and Wanfang database.This meta-analysis was performed by searching RCT study literatures on the prognosis of patients with acute heart failure treated with uhrafiltration and by screening the search results according to the PRISMA declaration.Results We identified 12 RCTs with a total of 1,070 participants involved.Overall,as compared with routine diuretics treatment,ultrafiltration treatment did not significantly affect the serum creatinine levels [standard mean difference (SMD =-0.18,95％ CI:-0.47 to 0.10,P =0.21)],the estimated glomerular filtration rate (SMD=-0.38,95％ CI:-1.03 to 0.27,P=0.25),and the incidence rate of renal failure (RR =1.25,95％ CI:0.88 to 1.77,P =0.21).But,ultrafiltration treatment was associated with decreased serum sodium level (SMD =-0.38,95 ％ CI:-0.67 to-0.08,P =0.01),increased net fluid extraction volume (SMD =1.06,95 ％ CI:0.29 to 1.83,P =0.007),and decreased body weight (SMD =-1.34,95％ CI:-1.98 to-0.71,P ＜ 0.001) Conclusions Although ultrafiltration increases the fluid extraction and decreases the fluid retention,the renal function and risk of renal failure in patients with acute heart failure are not significantly changed.
