Analysis on the clinical, neuroimaging and pathological characteristics in patients with corticobasal syndrome
10.3760/cma.j.issn.0254-9026.2018.07.005
- VernacularTitle:皮质基底节综合征患者临床表现影像学及病理学特点分析
- Author:
Xiaodan WANG
1
;
Shuai LIU
;
Zhihong SHI
;
Yong JI
Author Information
1. 300350,天津市环湖医院神经内科
- Keywords:
Pathology;
Neuroimaging;
Corticobasal syndrome
- From:
Chinese Journal of Geriatrics
2018;37(7):747-751
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical,neuroimaging and pathological features of patients with corticobasal syndrome (CBS).Methods Three CBS patients underwent neuropsychological assessment,MRI scan,18F-FDG PET scan,and 11C-PiB PET scan,and the test results were analyzed.Results All three patients showed poor response to levodopa treatment and asymmetric dyskinesia including rigidity,tremor,dystonia and abnormalities in posture and gait.One patient showed apraxia and three patients presented with cognitive impairment.The crania MRI demonstrated mild cerebral atrophy which was slightly more severe in the contralateral side of the initially affected limb.The (18)F-FDG PET/CT scan revealed asymmetric decreased metabolism in the frontal,parietal,temporal,and insular lobe,as well as in basal ganglia.The results of (11)C-PiB PET showed that amyloid beta-peptide (A Beta) deposition in the cortex was positive in one patient,and negative in the other two patients.Conclusions Corticobasal syndrome is characterized by asymmetric dyskinesia and cognitive impairment,and often associated with apraxia,cortical sensory deficits,and alien limb phenomena.The MRI and FDG PET are helpful for CBS diagnosis,and the PiB PET facilitates the pathological diagnosis.
