Effects of aging on the risk of developing coronary artery disease ,type 2 diabetes mellitus and both diseases in and elderly patients

VernacularTitle:增龄对冠心病和2型糖尿病及其共病患病风险和临床特点的比较研究
Author: Yanrong LI ^{1
,

2} ; Dengfeng ZHANG ; Liang SUN ; Fan YANG ; Ze YANG ; Deping LIU
Author Information

1. 100730 中国医学科学院北京协和医学院研究生院
2. 100730 北京医院国家老年医学中心心内科
Keywords: Aging; Coronary disease; Comorbidity
From: Chinese Journal of Geriatrics 2018;37(6):658-662
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between advancing age and the risk of developing coronary artery disease(CAD) ,type 2 diabetes mellitus(T2DM ) ,and both coronary artery disease and type 2 diabetes mellitus(CAD+ T2DM ). Methods A case-control study was conducted to investigate the relationship between advancing age and the risk of CAD ,T2DM ,and CAD+ T2DM in middle-aged and elderly patients. Results Aging was independently associated with increased risk of T2DM and CAD + T2DM (P＜0.05).Compared with patients aged below 60 ,the risk of T2DM was higher in patients aged 70 or over(OR＝3.80 ,95% CI :2.39-6.04 ,P＝0.000) ;The risk of CAD+ T2DM was lower in patients aged below 60 than in patients aged 60 to 69(OR＝4.14 ,95% CI :2.60-6.60 ,P＝ 0.000)and in patients aged 70 or over (OR ＝ 11.50 ,95% CI :7.18-18.42 ,P＝ 0.000) . Patients of older ages had a 2.78 times higher risk of developing CAD+ T2DM. Conclusions The onset of T2DM ,and CAD+ T2DM is associated with age.