Research advances in the role of polyamine metabolism in aging and heart failure
10.3760/cma.j.issn.0254-9026.2018.05.029
- VernacularTitle:多胺代谢在衰老和心力衰竭过程中的作用及研究进展
- Author:
Ning ZHANG
1
;
Wenying WEI
;
Yan CHE
;
Qizhu TANG
Author Information
1. 430060,武汉大学人民医院心内科
- Keywords:
Polyamines;
Aging;
Heart failure;
Prognosis
- From:
Chinese Journal of Geriatrics
2018;37(5):598-600
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of aging-induced heart failure has increased.Spermidine,spermine,and putrescine,the intermediate metabolites of polyamine metabolism,not only participate in an array of crucial molecular interactions with DNA,RNA,and proteins involved in gene transcription and cell division,but also change with aging and age-associated cardiac dysfunction.Detection of serum polyamine metabolites and B type natriuretic peptide(BNP)may open up new ways for the assessment of aging and aging-induced cardiac dysfunction.
