Research progress on the pathogenesis of sarcopenia in chronic kidney disease
10.3760/cma.j.issn.0254-9026.2018.05.028
- VernacularTitle:慢性肾脏病肌少症发病机制研究进展
- Author:
Yumei LI
1
;
Lailiang WANG
;
Qun LUO
Author Information
1. 315211,宁波大学医学院
- Keywords:
Kidney disease;
Sarcopenia
- From:
Chinese Journal of Geriatrics
2018;37(5):594-597
- CountryChina
- Language:Chinese
-
Abstract:
Sarcopenia is a degenerative syndrome mainly characterized by the atrophy of skeletal muscle,along with the decrease of muscle strength and function.Chronic kidney disease,especially in patients undergoing maintenance hemodialysis,can accelerate muscle consumption and increase the incidence rate of sarcopenia.Several factors were correlated with sarcopenia occurrence in chronic kidney disease,including inflammation,malnutrition,increased angiotensin Ⅱ,abnormal insulinsignaling pathway,abnormalities in myogenic regulatory factors,decreased hypogonadism,increased myostatins,mitochondrial disorders,decreased physical activity,etc.This paper has reviewed the research progress on the pathogenesis of sarcopenia in chronic kidney disease.
