Association of frailty syndrome with serum inflammatory biomarkers and geriatric parameters
10.3760/cma.j.issn.0254-9026.2018.05.024
- VernacularTitle:老年人衰弱与血清炎性因子和衰老因子的相关性
- Author:
Lin SU
1
;
Qiukui HAO
;
Ying YANG
;
Birong DONG
Author Information
1. 四川大学华西老年医学中心华西国家老年疾病临床研究中心四川养老与老年健康协同创新中心
- Keywords:
Frailty;
Chemokines;
Aging
- From:
Chinese Journal of Geriatrics
2018;37(5):579-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of frailty with serum inflammatory biomarkers and geriatric parameters.Methods A total of 299 elderly people aged 60 and over were recruited,received frailty and comprehensive geriatric assessment,and were tested on serum levels of interleukin-10 (IL-10),interleukin-1β (IL-1β),monocyte chemoattractant protein-1 (MCP-1),monocyte chemoattractant protein-3 (MCP-3),macrophage inflammatory protein 1a (MIP-1α),macrophage inflammatory protein-1β (MIP-1β),tumor necrosis factor α (TNF-α),nuclear factor-κB (NF-κB) and sirtuin-1 (SIRT-1).Potential association of frailty with these biomarkers and several geriatric parameters was analyzed.Results Statistical differences in serum levels of MCP-1,MIP-1α and MIP-1β were detected between the frailty group and the non-frailty group (H=10.766,10.766 and 8.217,respectively;P =0.005,0.043 and 0.016,respectively).Logistic regression analyses showed that MCP-1 and MIP-1β were associated with frailty after adjustment for age,sex,body mass index (BMI),smoking,drinking,comorbidity and comprehensive geriatric assessment (OR=2.493,2.531,both F＜0.05).Conclusions MCP-1 and MIP-1β are risk factors for frailty.
