The correlation between miRNAs levels and the pathogenesis of diabetes mellitus
10.3760/cma.j.issn.0254-9026.2018.05.011
- VernacularTitle:miRNAs水平与老年人糖尿病发病的相关性研究
- Author:
Hua LI
1
;
Tianyi LI
;
Ruiqiang WANG
;
Wenjun JIAO
;
Cong WU
Author Information
1. 450000,郑州大学第一附属医院老年内分泌科
- Keywords:
Diabetes mellitus;
MicroRNAs
- From:
Chinese Journal of Geriatrics
2018;37(5):528-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the expression levels of miRNAs and the pathogenesis of diabetes mellitus.Methods A total of 120 patients with type 2 diabetes recruited from October 2014 to October 2016 and 40 healthy individuals as a control group were included in this study,and diabetic patients were further divided into newly diagnosed group(n=40),prediabetes group(n =40),and susceptibility group (n =40).The fasting blood of four groups were collected,and real-time RT-PCR was applied to measure the expression levels of miRNAs including miR-9,miR-124a,miR-375,miR-29a,miR-126,miR-197,miR-233,and miR-320.The relationship between the pathogenesis of disease and miRNAs expression levels was analyzed.Results The levels of miRNA in the three diabetes groups were obviously higher than in the control group(P＜ 0.05).The miRNA expression level showed a certain trend in diabetic patients.The higher levels of miR-9,miR-124a,miR-375,and miR-29a were observed in the three diabetes groups,while the levels of miR-126,miR-197,miR-233,and miR-320 were decreased in these three groups.The expression levels of miR-9,miR 124a,miR-375,and miR-29a of miRNAs were correlated with the onset of diabetes(RR =5.96,6.32,5.24.5.69,all P＜ 0.05).Conclusions The level of miRNA is associated with the onset of diabetes that suggests it may be used to predict the occurrence and development of diabetes.
