Arterial endothelial dysfunction in stable chronic obstructive pulmonary disease patients and the correlation between the degree of endothelial dysfunction and the severity of chronic obstructive pulmonary disease
10.3760/cma.j.issn.0254-9026.2018.05.007
- VernacularTitle:慢性阻塞性肺病患者的血管内皮功能损伤程度与其严重程度的相关性
- Author:
Lili MA
1
;
Lin JIANG
;
Li FU
;
Li LI
;
Dong XU
;
Tingting WANG
;
Zhenghao XUAN
;
Jian ZHANG
Author Information
1. 100050,首都医科大学附属北京友谊医院国际医疗中心
- Keywords:
Vascular endothelium;
Pulmonary disease,chronic obstructive;
Nitric oxide
- From:
Chinese Journal of Geriatrics
2018;37(5):514-517
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate arterial endothelial dysfunction in stable chronic obstructive pulmonary disease (COPD) patients and the correlation between the degree of endothelial dysfunction and the severity of COPD.Methods Forty stable COPD patients were enrolled in a COPD group and 30 non-COPD individuals in a control group.The endothelium-dependent flow-mediated vasodilatation (FMD) of the brachial artery and serum eNO value were measured in both groups.Forced expiratory volume in 1 second (FEV1)/prediction of FEV1 was determined and expressed as FEV1 (％ pred).Results The mean FMD was significantly lower in the COPD group (11.21±5.19) ％ than in the control group (19.86±5.24)％ (t=6.090,P=0.001).The Pearson's correlation analysis showed FMD was positively correlated with FEV1 (％pred) in COPD patients (r=0.440,P＜0.05).The mean serum eNO level in the COPD group (108.58 ± 42.22) μmol/L was significantly lower than in the control group (151.17 ± 97.40)μmol/L (t =2.242,P =0.039).Conclusions The endothelium-dependent flow-mediated vasodilatation is significantly impaired in stable COPD patients,and the degree of impairment is proportional to the FEV1 (％ prediction of FEV1) in COPD patients.
