Prevalence and risk factors for atherosclerotic renal artery stenosis in elderly patients with refractory hypertension
10.3760/cma.j.issn.0254-9026.2018.03.005
- VernacularTitle:老年难治性高血压患者肾动脉粥样硬化性狭窄的发病情况及相关危险因素分析
- Author:
Hu AI
1
;
Huiping ZHANG
;
Guodong TANG
;
Hui LI
;
Ying ZHAO
;
Fucheng SUN
;
Jiefu YANG
Author Information
1. 100730,北京大学第五临床医学院北京医院国家老年医学中心心内科
- Keywords:
Hypertension;
Atherosclerosis;
Risk factors;
Renal artery stenosis
- From:
Chinese Journal of Geriatrics
2018;37(3):264-267
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence and risk factors for atherosclerotic renal artery stenosis (ARAS) in elderly patients with refractory hypertension.Methods Two hundred and eight elderly patients with a mean age of (68.3±4.9)years (53.8％ in men) diagnosed with refractory hypertension were recruited in this retrospective study from January 2010 to January 2017 in Beijing hospital.Fifty of the 208 patients with ultrasonography-suspected renal artery stenosis received renal arteriography and 39 were confirmed as renal artery stenosis.Renal artery stenosis was defined when stenosis located in at least one of renal arteries and only if the stenosis equal or over 50％.The prevalence of ARAS was calculated.Besides,univariate and final multivariate Logistic regression analyses were conducted to detect independent risk factors for development of ARAS.Results Thirty-nine of 208 patients (18.8％) were confirmatively diagnosed as ARAS.Although univariate Logistic regression showed that diabetes,coronary heart disease,renal insufficiency,and peripheral artery disease (P=0.034,0.040,0.022,and 0.030) might be risk factors for ARAS,a multivariate regression analysis demonstrated that only the peripheral artery disease (OR=3.218,P＜0.01) and renal insufficiency (OR=3.827,P＜0.01) were independent risk factors for ARAS.Conclusions Renal angiography should routinely be performed in refractory hypertension patients with renal insufficiency or peripheral artery disease to identify ARAS in time.
