Influencing factors of clinical outcome in elderly acute ischemic stroke patients after intravenous thrombolysis
10.3969/j.issn.1009-0126.2018.06.017
- VernacularTitle:老年急性脑梗死患者静脉溶栓治疗临床预后的影响因素分析
- Author:
Shuying XIAO
1
;
Yanna TONG
;
Fanhua MENG
;
Huishan DU
;
Qin ZHANG
;
Ting AO
;
Ruihua ZHANG
Author Information
1. 101149,首都医科大学附属北京潞河医院老年医学科
- Keywords:
brain infarction;
thrombolytic therapy;
C-reactive protein;
cerebral hemorrhage
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(6):623-626
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influencing factors of clinical outcome in elderly acute ischemic stroke (AIS) patients after intravenous thrombolysis.Methods One hundred and fifty-one AIS patients admitted to our hospital for intravenous thrombolysis were divided into good outcome group (n=77) and poor outcome group (n=74) according to their modified Rankin scale score 3 months after the onset of AIS.The baseline data,thrombolysis time window,NIHSS score and ischemic stroke typing before thrombolysis,early symptom improvement,cerebral hemorrhage after thrombolysis were compared between the two groups.Results The serum levels of blood glucose and CRP,NIHSS score≥9 before thrombolysis,incidence of AF and cerebral hemorrhage were significantly higher in poor outcome group than in good outcome group (P＜ 0.05,P＜0.01).Multivariate logistic regression analysis showed that NIHSS score,OCSP typing,blood glucose before thrombolysis,24 h symptom improvement were the independent influencing factors of clinical outcome in elderly AIS patients (OR =1.262,95 ％ CI:1.075-1.482,P =0.005;OR =0.203,95％CI:0.066-0.628,P=0.006;OR=1.264,95％CI:1.042-1.532,P=0.017;OR=25.764,95％CI:5.131-129.361,P=0.000).Conclusion NIHSS score,OCSP typing,blood glucose before thrombolysis and 24 h symptom improvement are the independent influencing factors of clinical outcome in elderly AIS patients after intravenous thrombolysis.
