Relationship between fibroblast growth factor 21 and blood glucose after cardiac surgical operation
10.3969/j.issn.1009-0126.2018.06.011
- VernacularTitle:心脏外科术后成纤维细胞生长因子21变化与血糖相关性研究
- Author:
Dingxu GONG
1
;
Lin ZHANG
;
Ying ZHANG
;
Fang WANG
;
Hansong SUN
Author Information
1. 中国医学科学院中国协和医科大学阜外心血管病医院心脏外科
- Keywords:
fibroblast growth factors;
coronary artery bypass,off-pump;
coronary artery disease;
blood glucose
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(6):600-602
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between fibroblast growth factor 21 (FGF21) and blood glucose (BG) after cardiac surgical operation.Methods Eighty-six coronary atherosclerotic heart disease patients without DM were divided into postoperative normal BG group (n=46) and postoperative elevated BG group (n =40).Their preoperative baseline data were recorded,their plasma FGF21 level was measured before and after operation.The relationship between FGF21 and BG was analyzed by dual regression analysis.Results The serum FGF21 level was signifycantly higher in two groups after operation than before operation (7.49±0.53 μg/L vs 3.04±0.26 μg/L,P＜0.01) and in postoperative normal BG group than in postoperative elevated BG group (5.84±0.72 μg/L vs 2.84±0.46 μg/L,P＜0.01).The circulating FGF21 level was related with the postoperative elevated BG level (OR =10.67,95％CI:2.34-48.63,P＜0.01).Conclusion BG is closely related with FGF21 after coronary bypass,which is of great importance for the management of BG after cardiac surgical operation.
