Relationship between serum small dense LDL-C level and coronary heart disease
10.3969/j.issn.1009-0126.2018.06.008
- VernacularTitle:小而密低密度脂蛋白胆固醇在冠心病患者中的变化及其与冠心病的关系
- Author:
Xiaorui CHAI
1
;
Hongying CONG
;
Mingbao REN
Author Information
1. 中国医学科学院中国协和医科大学阜外心血管病医院实验诊断中心临床检验科
- Keywords:
cholesterol,LDL;
coronary disease;
coronary angiography;
dyslipidemias
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(6):589-592
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between sdLDL-C level and CHD.Methods Two hundred and thirty-one CHD patients were divided into carotid stenosis group (n=119) and carotid stenosis-free group (n=112).The relationship between serum sdLDL-C level and risk factors for CHD were analyzed by logistic stepwise regression analysis.Results The serum sdLDL-C level was significantly higher in carotid stenosis group than in carotid stenosis-free group (P＜0.05).The elevated rate of serum sdLDL-C level was significantly higher in carotid stenosis group than in carotid stenosis-free group when 1.39 mmol/L was set as its upper limit reference cutoff value (36.3％ vs 17.0％,P＜0.05).The serum levels of TC,LDL-C,apoB,D-dimer and Fib were significantly higher while those of HDL-C were significantly lower in carotid stenosis group than in carotid stenosis-free grou (P＜0.05).The serum levels of sdLDL-C were positively related with those of TC,LDL-C,apoB,D-dimer,Fib and negatively related with those of HDL-C (P＜0.01).Logistic stepwise regression analysis showed that TC,LDL-C,apoB,D-dimer,Fib and sdLDL-C were the independent risk factors for CHD (P＜0.05).Conclusion Serum sdLDL-C level is significantly higher in CHD patients and is thus an important risk factor for CHD.
