Value of endothelin-1 in predicting the outcome of stable coronary artery disease patients
10.3969/j.issn.1009-0126.2018.06.007
- VernacularTitle:血浆内皮素1水平对稳定性冠心病患者的预后价值探讨
- Author:
Yuanyuan LIU
1
;
Bingyang ZHOU
;
Yuanlin GUO
;
Chenggang ZHU
;
Naqiong WU
;
Ying GAO
;
Qiuting DONG
;
Jianjun LI
Author Information
1. 中国医学科学院中国协和医科大学阜外心血管病医院心内科
- Keywords:
endothelin-1;
coronary disease;
cardiovascular diseases;
prognosis
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(6):585-588
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the value of endothelin-1 (ET-1) in predicting the outcome of stable coronary artery disease (SCAD) patients.Methods A total of 3154 SCAD patients who were followed up for 24 months were divided into cardiocerebral vascular events group (n=189) and cardiocerebral vascular events-free group (n =2965).Their serum ET-1 level was measured by ELISA.The patients were further divided into ET-1 ＜0.3 pmol/L group (n=1588) and ET-1≥0.3 pmol/L group (n=1566).The value of ET-1 in predicting the end events was assessed by Cox regression analysis.The survival curve was plotted by Kaplan-Meier analysis.Results The serum ET-1 level was signify-cantly higher in cardiocerebral vascular events group than in cardiocerebral vascular events-free group (0.33 pmol/L vs 0.30 pmol/L,P=0.004).The incidence of clinical end events was significantly lower in ET-1 ≥0.3 pmol/L group than in ET-1 ＜0.3 pmol/L group (7.02％ vs 4.97％,P=0.015).Multivariable Cox regression analysis showed that ET-1 was a predictor of clinical end events (HR=1.656,95％CI:1.099-2.496,P=0.016).Kaplan-Meier analysis showed that the events-free survival rate was lower in patients with a higher serum ET-1 level than in those with a lower serum ET-1 level (P=0.016).Conclusion ET-1 is an important risk factor for the outcome of SCAD patients.Further studies are needed to confirm its long-term value in predicting the outcome of SCAD patients.
