Effect of vitamins B in reducing serum uric acid level and protecting vessel endothelium
10.3969/j.issn.1009-0126.2018.05.020
- VernacularTitle:不同种类B族维生素降低尿酸和保护血管内皮作用探讨
- Author:
Gao LIU
1
;
Jing DONG
;
Ping ZHU
Author Information
1. 解放军总医院南楼心血管内科 国家老年疾病临床医学研究中心
- Keywords:
hyperuricemia;
NF-kappa B;
vascular cell adhesion molecule-1
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(5):529-533
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of different kinds of vitamins B in reducing serum UA level and protecting vessel endothelial function in hyperuricemia mouse model.Methods Seventyseven Kunming mice were divided into control group (n=12),allopurinol group (n=13),VB2group (n=13),VB6 group (n=13),VB12 group (n=13),FA group (n=13) according to their BMI.Serum UA and NO levels were measured,and expressions of NF κB and VCAM-1 were detected with immunohistochemical staining.Results The serum UA level was significantly lower,the expression levels of NF-κB and VCAM-1 were significantly lower while the serum NO level was significantly higher in allopurinol group,VB groups and FA group than in control group (P＜0.01).The serum UA level was significantly higher while the serum NO level was significantly lower in VB2 group than in allopurinol group (P＜0.01).The serum NO level group was significantly higher in VB12 than in allopurinol group (P＜0.01).The positive expression levels of NFκB and VCAM-1 in aortic endothelium were higher in control group than in other groups,significantly higher in VB2 group than in allopurinol group and significantly lower in VB6 group,VB12group and FA group than in allopurinol group (P＜0.05,P＜0.01).Conclusion Different kinds of vitamins B can effectively reduce the serum UA level,increase the serum NO level,and inhibit the expressions of NF-κB and VCAM-1 in hyperuricemia mice.
