Effect of intensive atorvastatin therapy on blood glucose in acute coronary syndrome patients
10.3969/j.issn.1009-0126.2018.05.011
- VernacularTitle:急性冠状动脉综合征患者强化阿托伐他汀治疗对血糖的影响
- Author:
Peijin CHEN
1
;
Yingxia LIU
Author Information
1. 521000,潮州市人民医院心血管内科
- Keywords:
acute coronary syndrome;
antilipemic agents;
blood glucose;
diabetes mellitus
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(5):491-494
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of intensive atorvastatin therapy on blood glucose in ACS patients.Methods Two hundred ACS patients were divided into control group (n=100) and intensive atorvastatin therapy group (n=100).The patients in both groups underwent secondary preventive treatment of CHD.The patients in control group were treated with 20 mg oral atorvastatin before going to bed and those in intensive atorvastatin therapy group were treated with 40mg oral atorvastatin.The patients were followed up for 6 months,during which their serum levels of FPG,HbA1c,TC,TG,LDL-C and HDL-C were measured before and after treatment.Results The serum levels of HDL-C were significantly higher while those of TC,TG and LDL-C were significantly lower in control group after treatment than before treatment (P＜0.01).The serum levels of HDL-C,FPG and HbA1c were significantly higher while those of TC,TG and LDL-C were significantly lower in intensive atorvastatin therapy group after treatment than before treatment(P＜0.05,P＜0.01).The serum levels of HDL-C,FPG and HbA1c were significantly higher while those of TC and LDL-C were significantly lower in intensive atorvastatin therapy group after treatment than before treatment (1.48±0.39 mmol/L vs 1.36±0.20 mmol/L,P＜0.05;5.71±0.67 mmol/L vs 5.21±0.53 mmol/L,P＜0.01;5.44％±0.75％ vs 5.19％±0.31％,P＜0.01).Conclusion Intensive statin therapy can effectively reduce the serum lipid level,elevate the serum FPG level,and increase the risk of diabetes in ACS patients.
