Role of different dose nicorandil in prevention of contrast-induced nephropathy in elderly CHD patients
10.3969/j.issn.1009-0126.2018.05.010
- VernacularTitle:不同剂量尼可地尔对老年冠心病患者造影剂肾病的预防作用
- Author:
Kai ZHAO
1
;
Yongjian LI
;
Qiaoying GAO
;
Chunhui ZONG
;
Sheng GAO
Author Information
1. 300100,天津市南开医院心血管内科
- Keywords:
nicorandil;
coronary disease;
contrast media;
nephrosis;
glomerular filtration rate
- From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(5):487-490
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of different dose nicorandil in prevention of CIN in elderly CHD patients.Methods One hundred and twenty-one elderly CHD patients were divided into standard dose nicorandil treatment group (n=42),5 mg nicorandil treatment group (n=39) and 10 mg nicorandil treatment group (n=40).Their Scr levels,and eGFR were measured for 3 days before and after PCI.The urine KIM-1 and NGAL levels were measured before and 24 h after PCI.The incidence of CIN and adverse reactions were compared in 3 groups.Results The incidence of (IN and the eGFR ≥25％ were significantly lower,the serum Scr level was significantly lower while the eGFR was significantly higher in 5 mg and 10 mg nicorandil treatment groups than in standard dose nicorandil treatment group on days 1 and 2 after PCI (P＜0.05,P＜0.01).The serum Scr level was significantly lower while the eGFR was significantly higher in 10 mg nicorandil treatment group than in 5 mg nicorandil treatment group on day 2 after PCI (P＜0.05).The urine KIM-1 and NGAL level were significantly lower in 10 mg nicorandil treatment group than in standard dose nicorandil treatment group and 5 mg nicorandil treatment group at 24 h after PCI (2.77±0.33 μg/L vs 5.63±0.27 μg/L,4.82±0.32 μg/L,P＜0.05;41.64±8.42 μg/L vs 66.51±10.72 μg/L,57.11±9.67 μg/L,P＜0.05).Conclusion Different oral doses of nicorandil play a role in prevention of CIN and 10 mg nicorandil plays a greater role than standard dose nicorandil and 5 mg nicorandil in prevention of CIN in elderly CHD patients undergoing PCI.
