Effect of trimetazidine on expression of HSP70 and Mn-SOD after myocardial ischemia/reperfusion in rats
10.3969/j.issn.1009-0126.2018.04.019
- VernacularTitle:曲美他嗪对大鼠心肌缺血再灌注后热休克蛋白70及超氧化物歧化酶表达的影响
- Author:
Zhiying ZHONG
1
;
Yu TANG
;
Tugang CHEN
;
Zhanqing MA
;
Weiling TAN
;
Lina GE
;
Ruihong LIU
;
Yu ZHAO
Author Information
1. 330000,南昌大学第四附属医院老年医学科
- Keywords:
trimetazidine;
myocardial reperfusion injury;
HSP70 heat-shock proteins;
malondialdehyde
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(4):408-411
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effect of trimetazidine pretreatment on myocardial I/R in a rat I/R model and its mechanism.Methods One hundred and twenty SD rats were divided into control group,I/R group,HSP70 inhibitor group,trimetazidine treatment group and combined treatment group (24 in each group).The rats in each group were further divided into 30 min reperfusion group,4 h reperfusion group and 8 h reperfusion group (8 in each group).Their HSP70-positive myocardial cells were calculated,their serum CK,CK-MB,MDA,SOD levels and their myocardial infarction size were measured.Results The serum CK and CK-MB levels were significantly higher in I/R group,HSP70 inhibitor group,trimetazidine treatment group and combined treatment group than in control group and were significantly lower in trimetazidine treatment group than in combined treatment group and I/R group after reperfusion for 4 and 8 h (P＜0.01).The serum levels of HSP70 and SOD were significantly higher,the MDA levels were significantly lower in trimetazidine treatment group than in combined treatment group and I/R group after reperfusion for 30 min,4 and 8 h (P＜0.01).The infraction size was significantly smaller in trimetazidine treatment group than in combined treatment group and I/R group after reperfusion for 4 and 8 h (P＜0.05).Conclusion Trimetazidine can increase the serum HSP70 level in myocardial cells,reduce the infarction size,and protect the myocardium against I/R in rats.
