Relationship of early neurological deterioration with HDL-C and Lp (a) in acute cerebral infarction
10.3969/j.issn.1009-0126.2018.04.018
- VernacularTitle:急性脑梗死早期神经功能恶化与高密度脂蛋白胆固醇及脂蛋白(a)的关系
- Author:
Jian HUA
1
;
Qida ZHOU
Author Information
1. 214011,无锡市锡山人民医院神经内科
- Keywords:
brain infarction;
atherosclerosis;
lipoprotein(a);
cholesterol,HDL;
dyslipidemias
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(4):405-407
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between early neurological deterioration (END) and serum lipid level in acute cerebral infarction (ACI) due to large artery atherosclerosis (LAA).Methods One hundred and thirty-six LAA-induced ACI patients were divided into END group (n=57) and control group (n=79).Their baseline clinical data were recorded,and their serum levels of TC,TG,LDL-C,HDL-C,apoB,Lp (a) were measured.Results No significant difference was found in gender,incidence of DM and hypertension,history of smoking,NIHSS score,serum TG and Lp (a) level between END group and control group (P＞0.05).The serum levels of TC,LDL-C,apoB and Lp (a) were significantly higher while the age was significantly younger and the serum HDL-C level was significantly lower in END group than in control group (5.09± 1.49 mmol/L vs 4.58±0.99 mmol/L,P=0.016;3.20±1.36 mmol/L vs 2.68±0.80 mmol/L,P=0.022;1.14±0.38 g/L vs 0.95±0.24 g/L,P=0.004;277.16±243.90 mg/L vs 157.99±149.11 mg/L,P=0.020;65.95±10.94 years vs 70.08±10.98 years,P=0.032;1.13±0.30 mmol/L vs 1.32±0.44 mmol/L,P=0.007).Serum Lp (a) and HDL-C levels were related with END (P=0.006,P=0.019).Spearman correlation analysis showed that Lp (a) was not related with HDL-C (r=0.092,P=0.288).Conclusion Elevated serum HDL-C and Lp (a) levels are an independent risk factor for END in ACI patients and play a certain role in clinical assessment of END.
