Relationship between severity of CHD and risk of cardiovascular events in a population with different ABO blood types
10.3969/j.issn.1009-0126.2018.04.007
- VernacularTitle:不同ABO血型人群冠状动脉病变严重程度及心血管事件的风险分析
- Author:
Qiuting DONG
1
;
Yan ZHANG
;
Sha LI
;
Ying GAO
;
Chenggang ZHU
;
Naqiong WU
;
Yuanlin GUO
;
Qian DONG
;
Geng LIU
;
Jianjun LI
Author Information
1. 国家心血管病中心中国医学科学院阜外医院血脂中心
- Keywords:
coronary disease;
coronary angiography;
atherosclerosis;
ABO blood-group system
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(4):363-366
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of different ABO blood types with the risk of cardiovascular events and the severity of CHD.Methods A total of coronary arteriography-confirmed 3823 Chinese Han CHD patients were divided into O blood type group (n=1140) and non-O blood type group (n=2683).A total of 3654 patients who were followed up by telephone for a median period of 24.6 months were divided into cardiovascular events group (n=348) and cardiovascular events-free group (n =3306).The risk of cardiovascular events in CHD patients with different ABO blood types was assessed according to the Cox proportional hazards model.Results The incidence of left main branch lesion or 3-branch lesions was significantly higher in cardiovascular events group than in cardiovascular events-free group (15.2％ vs 8.1％,47.7％ vs 30.5％,P＜0.01).The Gensini score was significantly higher in non-O blood type group than in O blood type group (20 vs 18,P＜0.05).The incidence of cardiovascular events was higher in non-O blood type group than in O blood type group (10.3％ vs 7.8％,P=0.019).Cox proportional hazards model showed that non-O blood type was an risk factor for cardiovascular events (HR =1.318,95 ％CI:1.030-1.685).The risk of cardiovascular events was still higher in non-O blood type group than in O blood type group after adjustment for confounders (HR=1.291,95％CI:1.008-1.657,P=0.046).Conclusion Non-O blood type is closely related with cardiovascular events in Chinese Han CHD patients.
