Effect of hypertension on motor function in Parkinson's disease patients with white matter lesion
10.3969/j.issn.1009-0126.2018.03.017
- VernacularTitle:高血压对帕金森病伴脑白质病变患者运动功能的影响
- Author:
Zeyan PENG
1
;
Shuyang DONG
;
Yong TAO
;
Yingchao HUO
;
Huadong ZHOU
Author Information
1. 233030,蚌埠医学院研究生院
- Keywords:
hypertension;
Parkinson disease;
movement disorders;
diabetes mellitus;
hyperlipidemias;
leukoaraiosis
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(3):286-289
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of hypertension on motor function in Parkinson's disease (PD) patients with white matter lesion (WML).Methods Two hundred and nineteen PD patients with WML were divided into hypokinesia group (n=137) and non hypokinesia group (n=82).The patients were followed up for 1 year.The relationship of vascular risk factors with hypertension and hypokinesia was analyzed.Results The age was older,the incidence of hypertension,DM and lipidemia was higher,the SBP and DBP were higher in hypokinesia group than in non hypokinesia group (P＜0.01,P＜0.05).Logistics regression analysis showed that age,hypertension and DM were the risk factors for hypokinesia in PD patients with WML (OR =1.78,95 ％CI:1.43-2.14,OR =1.97,95 ％0 CI:1.49-2.52,OR =1.63,95 ％ CI:1.31-1.94).Further analysis showed that grade 2 and 3 hypertension were closely related the risk of hypokinesia in PD patients with WML(OR=1.62,95％CI:1.29-1.95;OR=2.19,95％CI:1.49-2.91).Conclusion Hypertension,especially grade 2 and 3 hypertension,can aggravate hypokinesia in PD patients with WML.
