Relationship between phosphodiesterase 4D gene rs966221 single nucleotide polymorphisms and ischemic stroke
10.3969/j.issn.1009-0126.2018.03.013
- VernacularTitle:磷酸二酯酶4D基因rs966221位点单核苷酸多态性与缺血性脑卒中发病的关系
- Author:
Dongdong JIANG
1
;
Haihua LI
;
Jianli LI
;
Yousheng XIAO
;
Lu GAN
;
Man LUO
Author Information
1. 广西医科大学第一附属医院神经内科
- Keywords:
cyclic nucleotide phosphodiesterases,type 4;
polymorphism,single nucleotide;
gene frequency;
genotype;
stroke;
magnetic resonance imaging
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(3):271-274
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between phosphodiesterase 4D (PDE4D) gene rs966221 single nucleotide polymorphisms (SNPs) and ischemic stroke (IS) in Guangxi Zhuang population.Methods One hundred and one IS patients from Guangxi Zhuang Autonomous Region served as IS pgroup and 104 healthy subjects undergoing physical ecamination served as control group in this study.Their PDE4D gene rs966221 SNPs were detected by SNaPshot technique.The genotypes and frequencies of alleles were compared between the two groups and the relationship between PDE4D gene rs966221 SNPs and IS was analyzed.Results No significant difference was found in the GG,GA,AA genotypes and in the frequencies of G and A alleles between the two groups (0.99％ vs 3.85％,29.70％ vs 21.15％,69.31％ vs 75.00％,P＞0.05;15.84％ vs 14.42％,84.16％ vs 85.58％,P＞0.05).Univariate and multivariate logistic regression analysis showed that the PDE4D gene rs966221 SNPs were not related with the risk of IS in dominant AA vs GG+GA,recessive GG vs AA+GA and additive GG vs AA genetic models (P＞0.05).Conclusion The PDE4D gene rs966221 SNPs are not related with IS in Guangxi Zhuang population.
