Association between morning surge of systolic blood pressure and white matter lesions in elderly hypertensive patients

VernacularTitle:老年高血压患者收缩压晨峰与脑白质损害的相关性
Author: Wenjing HU ¹ ; Hongxia LIU ; Juan WANG ; Tiantian JI ; Dandan DUAN ; Hua ZHANG ; Shangwen SUN ; Qiang CHAI ; Zhendong LIU
Author Information

1. 250200,济南大学山东省医学科学院医学与生命科学学院
Keywords: hypertension; circadian rhythm; blood pressure; blood pressure monitoring,ambulatory
From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases 2018;20(3):268-270
CountryChina
Language:Chinese
Abstract: Objective To study the association between morning surge (MS) of systolic blood pressure (SBP) and white matter lesions in elderly essential hypertensive (EH) patients.Methods Three hundred and thirty-seven elderly EH patients from Zhangqiu of Shandong Province were divided into MS group (n=150) and non-MS group (n=187).Their 24 h ambulatory SBP was monitored.Their white matter hyperintensity (WMH) was assessed according to their brain MRI.Results The total WMH,periventricular WMH,and deep WMH were significantly higher in MS group than in non-MS group (P＜0.01).The MS of SBP was positively related with the total WMH,periventricular WMH,and deep WMH (r=0.561,r=0.563,r=0.283,P＜0.01),and was an independent risk factor for total WMH,periventricular WMH,and deep WMH after adjustment for confunders (r=0.479,r=0.486,r=0.208,P＜0.01).Conclusion MS of SBP is an independently risk factor for WMH in elderly EH patients.