Association between single nucleotide polymorphism of SEPT14 gene and sporadic PD
10.3969/j.issn.1009-0126.2018.03.011
- VernacularTitle:SEPT14基因单核苷酸多态性与散发性帕金森病的相关性研究
- Author:
Yanxin LI
1
;
Quanquan WANG
;
Xiaoma JING
;
Yanlei HAO
;
Yan YANG
;
Zhanyun LV
Author Information
1. 山东大学医学院
- Keywords:
polymorphism,single nucleotide;
Parkinson disease;
alleles;
gene frequency
- From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(3):263-267
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association between the single nucleotide polymorphism (SNP) of SEPT14 (rs77231105,rs10241628,rs11981883,rs73701167) and sporadic PD in Chinese Han populationin of Southwest Shandong.Methods One hundred and eighty PD patients from Southwest Shandong served as PD patient group and 200 healthy subjects from Southwest Shandong served as control group in this study.The distribution frequencies of alleles and genotypes in SNP of rs77231105,rs10241628,rs11981883 and rs73701167 were compared by PCR and sequencing respectively.Results No significant difference was found in the distribution frequencies of alleles and genotypes in rs77231105,rs10241628,rs11981883 between the two groups (P＞0.05).The distribution frequency of rs73701167 was significantly higher in PD patient group than in control group (31.1％ vs 20.5％,OR=1.75,95％CI=1.261-2.428,P=0.001).Conclusion The SNP of SEPT14 rs77231105,rs10241628 and rs1198188 are not associated with PD,the SNP of rs73701167 is associated with PD in Chinese Han population of Southwest Shandong.The allele C is a risk factor for PD.
