Effect of combined atorvastatin and ezetimibe pretreatment on perioperative hs-CRP after elective PCI
10.3969/j.issn.1009-0126.2018.03.010
- VernacularTitle:阿托伐他汀联用依折麦布预处理对择期介入治疗围术期高敏C反应蛋白的影响
- Author:
Jie ZHANG
1
;
Ying ZHANG
;
Hongxing SONG
;
Ran HE
;
Heli GUO
;
Yiqiang YUAN
;
Huailin LIU
Author Information
1. 450016,郑州市心血管病医院 郑州市第七人民医院心内科
- Keywords:
intraoperative period;
C-reactive protein;
angina pectoris;
antilipemic agents
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(3):260-262
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of combined atorvastatin and ezetimibe pretreatment on perioperative hs-CRP after elective PCI.Methods One hundred and fifty-six patients with typical chronic stable angina pectoris were randomly divided into atorvastatin treatment group (n=78) and combined atorvastatin and ezetimibe treatment group (n=78).Their serum hs-CRP,TC and LDL-C level was measured before PCI,at hours 8,24,48 and on day 7 after PCI.Results In comparision with pre-operation,the serum TC and LDL-C levels were significantly lower in two groups (P＜0.01) and in combined atorvastatin and ezetimibe treatment group than in atorvastatin treatment group on day 7 after PCI (P＜0.05).The serum hs-CRP level was significantly higher in two groups at 8 h after PCI than before PCI,reached its peak at 24 h after PCI,continued to increase at 48 h after PCI (P＜0.01),no significant difference was found between the two groups on day 7 after PCI (P＞0.05).The average serum hs-CRP level was lower in combined atorvastatin and ezetimibe treatment group than in atorvastatin treatment group at hours 8,24 and 48 after PCI (P＜0.05) with no significant change found between the two groups on day 7 after PCI (P＞0.05).Conclusion The effect of combined atorvastatin and ezetimibe pretreatment is better than that of atorvastatin alone on perioperative acute inflammatory reactions after PCI.
