Effect of combined domestic clopidogrel and tongxinluo on major adverse cardiovacular events after PCI
10.3969/j.issn.1009-0126.2018.03.005
- VernacularTitle:国产氯吡格雷联合通心络对介入治疗术后不良事件的影响
- Author:
Wenbin SHEN
1
;
Shiqiang WEI
;
Hongqi FENG
;
Qiongli CHEN
;
Huijun LIU
;
Ruixia ZHANG
;
Tao MA
;
Jing BAI
;
Yu WANG
Author Information
1. 解放军第三七一医院心内科
- Keywords:
thrombelastography;
platelet aggregation inhibitors;
aspirin;
arachidonic acid;
platelet activating factor
- From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(3):243-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the platelet inhibition rate of foreign clopidogrel,domestic clopidogrel,combined domestic clopidogrel and tongxinluo and their effct on major adverse cardiovacular events (MACE) after PCI.Methods Two hundred and twenty patients after PCI were divided into foreign clopidogrel treatment group (n=77),domestic clopidogrel treatment group (n=80),combined domesticclopidogrel and tongxinluo treatment group (n =63).The high platelet reactivity (HPR) in 3 groups was detected by thrombelastography after PCI.The incidence of MACE in 3 groups was compared.Results The incidence of left anterior descending branch lesion was lower,the number of sacculi was smaller,and the incidence of HPR was higher in foreign clopidogrel treatment group than in domestic clopidogrel treatment group and combined domestic clopidogrel and tongxinluo treatment group after PCI (63.6％ vs 87.5％ vs 77.8％,P=0.002;2.3±1.1 vs 2.8±1.4 vs 2.7±1.5,P=0.026;24.7％ vs 21.3％ vs 11.1％,P=0.030).The incidence of HPR was significantly higher in foreign clopidogrel treatment group than in combined domestic clopidogrel and tongxinluo treatment group (24.7 ％ vs 11.1％,P =0.040).No significant difference was found in the incidence of MACE in 3 groups (P ＞ 0.05).Conclusion The incidences of MACE of domestic clopidogrel and foreign clopidogrel are similar.Combined clopidogrel and tongxinluo can improve the platelet inhibition rate after PCI.
