Effect of citicoline on mild cognitive impairment in patients with middle cerebral artery stenosis
10.3969/j.issn.1009-0126.2018.02.018
- VernacularTitle:胞磷胆碱对大脑中动脉狭窄患者轻度认知功能障碍的影响
- Author:
Xuanjun LIU
1
;
Guoshuai YANG
;
Yujie HU
;
Qihui CHENG
;
Haiyan WU
;
Lv ZHOU
;
Yanjun ZHANG
Author Information
1. 570208,中南大学湘雅医学院附属海口医院神经内科
- Keywords:
cytidine diphosphate choline;
middle cerebral artery;
cognition disorders;
ultrasonography,Doppler,transcranial
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(2):179-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of citicoline on mild cognitive impairment MCI) in pa tients with middle cerebral artery stenosis (MCAS).Methods Eighty-six MCAS patients with MCI were divided into citicoline group (n=44) and control group (n=42).The patients in citicoline group were treated with citicoline (0.2 g,3 times a day) for 6 months on the basis of conventional treatment.Cerebrovascular reserve,PI,BHI and Vm between the two groups were compared by transcranial Doppler ultrasonography after treatment.MCI between the two groups was assessed according to the MoCA after treatment.Results The rate of cerebrovascular reserve,PI,BHI and Vm were significantly higher in citicoline group than in control group (13.59％± 1.16％ vs 7.61％±1.12％,P＜0.01;0.51±0.16 vs 0.58±0.12,P＜0.05;1.36±0.08 vs 0.74±0.11,P＜ 0.01;32.63％ ±2.32％ vs 16.92％ ± 1.68％,P＜0.05).The total MoCA score,attention,language,visuospatial and executive function,abstract,naming,orientation and memory were significantly higher in citicoline group than in control group (P＜0.01).Conclusion Early citicoline treatment can improve cerebrovascular reserve and alleviate MCI in MCAS patients.
