Association between serum albumin level and first-onset acute myocardial infarction
10.3969/j.issn.1009-0126.2018.02.011
- VernacularTitle:血清白蛋白水平与初发急性心肌梗死的相关性研究
- Author:
Ming XIA
1
;
Jian GU
;
Chi ZHANG
;
Yongmin HE
;
Xiangjun YANG
Author Information
1. 215000,苏州大学附属第一医院心内科
- Keywords:
serum albumin;
myocardial infarction;
coronary disease;
food habits
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(2):153-157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association between serum albumin level and first-onset AMI.Methods A total of 2172 patients with first-onset AMI served as an observation group and 3395 CHD-free patients served as a control group.The association between serum albumin level and first-onset AMI was analyzed by logistic regression analysis.Results The serum albumin level was significantly lower in observation group than in control group (40.0 g/L vs 41.4 g/L,P=0.000).On a continuous scale,when serum albumin level decreased by 1 standard deviation (～4 g/L),adjusted OR (95％CI) was 1.87 (1.75-2.01),1.85 (1.71-2.01),1.48 (1.26-1.74) for AMI in the total patients,male patients and female patients,respectively.On a categorical scale,Q1 (albumin level ≥43.8 g/L) was used as reference.Stratifying by age showed that adjusted OR (95％CI) was Q2 1.43 (1.12-1.82),Q3 1.95 (1.53-2.47),Q4 2.52 (1.95-3.27),Q5 4.51 (3.40-6.00) for AMI in patients aged ＜65 years and was Q2 1.61 (1.042.5),Q3 2.21 (1.48-3.31),Q4 3.34 (2.244.99),Q5 4.77 (3.22-7.08) in patients aged ≥65 years (P-for-trend ＜ 0.01).Stratifying by gender showed that serum albumin level was negatively associated with AMI in both sexes (P-for-trend ＜0.01).Conclusions Serum albumin level is negatively associated with the risk of first-onset AMI in a dose-response manner regardless of stratifying by age and/or gender.
