Effect of telmisartan combined with rosuvastatin on white matter lesion in elderly hypertensive patients
10.3969/j.issn.1009-0126.2018.02.009
- VernacularTitle:替米沙坦联合瑞舒伐他汀对老年高血压患者脑白质损害的影响
- Author:
Yali CHEN
1
;
Hongxia LIU
;
Juan WANG
;
Tingting ZHOU
;
Shangwen SUN
;
Hua ZHANG
;
Dandan DUAN
;
Zhendong LIU
Author Information
1. 250200,济南大学 山东省医学科学院医学与生命科学学院
- Keywords:
hypertension;
magnetic resonance imaging;
dyslipidemias;
antilipemic agents;
antihypertensive agents;
leukoaraiosis
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(2):145-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of telmisartan combined with rosuvastatin on white matter lesion (WML) in elderly hypertensive patients.Metheds Three hundred and twenty-nine elderly patients with mild-moderate essential hypertension (EH) were divided into control group (n=167) and combined treatment group (n=162).The patients in control group were treated with telmisartan (40 mg/d) and those in combined treatment group were treated with telmisartan plus rosuvastatin (10 mg/d).Their white matter hyperintensivity (WMH),periventricular white matter hyperintensity (PWMH),and deep white matter hyperintensity (DWMH) were measured by head MRI.Results The total WMH,PWMH and DWMH were significantly higher in two groups in the third and fifth years than at the baseline (P＜0.05).The growth rate of total WMH,PWMH and DWMH was significantly lower in combined treatment group than in control group in the third and fifth years (P＜0.05).Conclusion Telmisartan combined with rosuvastatin plays an important role in stablizing blood pressure,regulating blood lipids,and delaying WML.
