Relationship between smoking and serum hs-CRP level in carotid atherosclerosis patients
10.3969/j.issn.1009-0126.2018.02.006
- VernacularTitle:吸烟与颈动脉粥样硬化患者血清高敏C反应蛋白水平的相关性研究
- Author:
Zhongying GONG
1
;
Yang YANG
;
Zhiyun WANG
;
Dawei ZANG
;
Wei LIU
Author Information
1. 300192,天津医科大学一中心临床学院神经内科
- Keywords:
carotid artery diseases;
atherosclerosis;
C-reactive protein;
smoking
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(2):133-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical significance of serum hs-CRP level in smokers with carotid atherosclerosis (CA) and analyze its difference in subtypes of CA.Methods Two hundred and ninety-eight smokers with CA served as a smoker group and 120 non-smokers with CA served as a non-smoker group,50 healthy smokers without CA served as control group 1 and 50 healthy non-smokers served as control group 2.Their serum hs-CRP level was measured by colloid-enhanced immunoturbidimetry.Smokers were divided into stable plaque group and unstable plaque group.Effect of smoking on serum hs-CRP level in CA patients was analyzed.Results The serum hs-CRP level was significantly higher in smoker group and control group 1 than in non-smoker group and control group 2 (7.26±4.24 mg/L vs 3.56±2.28 mg/L,4.34±2.74 mg/L vs 3.17± 1.68 mg/L,P＜0.05).The smoking index was positively related with the serum hs-CRP level (r=0.395,P＜0.01).The number of daily smoked cigarettes was significantly greater in unstable plaque group than in stable plaque group (P＜0.05).The recurrence rate of ischemic stroke was significantly higher in smokers with a high serum hs-CRP level than in those with a low serum hs-CRP level (11.36％ vs 2.00％,P＜0.01).Conclusion Smoking can increase the serum hs-CRP level in CA patients,which is closely related with the stability of plaques and the recurrence of ischemic stroke.
