Role of dynamic contrast enhanced MRI in assessing early curative effect of rosuvastatin on carotid atherosclerotic plaques
10.3969/j.issn.1009-0126.2018.02.004
- VernacularTitle:动态增强磁共振成像对瑞舒伐他汀治疗颈动脉粥样硬化斑块的早期疗效评价
- Author:
Danqing LIU
1
;
Ruixue DU
;
Qingjun WANG
;
Ping YE
;
Hongmei WU
;
Jianming CAI
Author Information
1. 100043,首都医科大学附属北京朝阳医院放射科
- Keywords:
magnetic resonance imaging;
carotid artery diseases;
atherosclerosis;
vasa vasorum;
antilipemic agents
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(2):126-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of dynamic contrast enhanced MRI (DCE-MRI) in assessing early curative effect of rosuvastatin on carotid atherosclerotic plaques.Methods Twenty-five patients with lipid-rich necrotic core carotid atherosclerotic plaques received intensive rosuvastatin treatment (5-20 mg/d) for 2 years,and carotid artery DCE-MRI at baseline before treatment and at months 3,12 and 24 after rosuvastatin treatment.Their adventitial transfer constant (K) and fractional plasma volume (Vp) were measured and compared during the rosuvastatin treatment.Results The Vp was significantly smaller at months 3,12 and 24 after rosuvastatin treatment than at baseline before rosuvastatin treatment (0.09±0.05,0.07±0.04 and 0.06±0.05 vs 0.12± 0.06,P＜0.05) with a reduction of 25.0％ after 3 months of rosuvastatin treatment and a gradual reduction after 24 months of rosuvastatin treatment (P＜0.05).The adventitial K was mildly reduced after 24 months of rosuvastatin treatment (P＞0.05).Conclusion DCE-MRI can assess the early curative effect of rosuvastatin on carotid atherosclerotic plaques.
