Relationship of CSF and serum FGF-2 level with clinical parameters in motor neuron disease patients
10.3969/j.issn.1009-0126.2018.01.014
- VernacularTitle:运动神经元病患者脑脊液及血清碱性成纤维细胞生长因子2与临床关系的研究
- Author:
Zhongying GONG
1
;
Lina GAO
;
Jie GUO
;
Yi LU
;
Dawei ZANG
Author Information
1. 300192,天津市第一中心医院神经内科
- Keywords:
motor neuron disease;
cerebrospinal fluid;
fibroblast growth factor 2
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(1):55-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of CSF and serum FGF-2 level with clinical parameters in MND patients.Methods Ninety-one MND patients served as a MND group and 40 noninflammtory nervous system disease patients served as a control group.Their CSF and serum FGF-2 level were measured by ELISA.The neurological deficit in ALS patients was assessed according to the modified ALSFRS-r,the progression of MND was assessed according to the DPR.The ALS patients were followed up,during which their survival time was recorded.Results The serum FGF-2 level was significantly higher in MND group than in control group (P＜0.01).The CSF,FGF-2 level were significantly higher in ALS patients of MND group than in those of control group (319.2±105.9 ng/L vs 241.7±34.3 ng/L,P＜0.01).The CSF and serum FGF-2 level were positively correlated with the duration of MND and negatively correlated with the DRP in ALS patients (P＜0.01).Survival analysis of MND patients indicated that the survival time of PMA patients was longer than that of PLS,ALS and PBP patients (P=0.000).The cumulative survival rate of ALS patients with a high serum FGF-2 level was significantly higher than that of those with a low serum FGF-2 level (P=0.002).Conclusion The CSF and serum FGF-2 level are higher in some MND patients and can be used as one of the biomarkers for evaluating the progression and predicting surrival.
