Effect of different atorvastatin doses on contrast-induced nephropathy after PCI
10.3969/j.issn.1009-0126.2018.01.009
- VernacularTitle:不同剂量阿托伐他汀对冠状动脉介入术后发生造影剂肾病的影响
- Author:
Xiaojin XU
1
;
Qing ZHANG
;
Hailang LIU
;
Xiwen ZHANG
;
Guiyuan CHEN
Author Information
1. 223300,南京医科大学附属淮安第一医院心内科
- Keywords:
antilipemic agents;
nephrosis;
contrast media;
coronary angiography;
apolipoproteins
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(1):32-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of different atorvastatin doses on contrast-induced nephropathy (CIN) and the role of neutrophil gelatinase-associated lipocalin (NGAL) in early diagnosis of CIN after PCI.Methods Two hundred and twelve patients admitted to our hospital for PCI from June 2015 to January 2017 were divided into high atorvastatin dose treatment group as group A (n=108) and conventional atorvastatin dose treatment group as group B (n=104).They underwent coronary arteriography and PCI.Their serum creatinine and urinary NGAL levels were measured before and at 4,24,48,72 h respectively after coronary arteriography and PCI.The role of urinary NGAL level in early diagnosis of CIN was analyzed according to its ROC curve.Results CIN occurred in 6 patients of group A and in 19 patients of group B with an incidence of 5.6％ and 18.3％ respectively (P=0.012).The urinary NGAL level was significantly higher in two groups at 4,24,48,72 h respectively after coronary arteriography and PCI than before coronary arteriography and PCI,reached its peak at 72 h,and was significantly higher in group B than in group A (P＜0.05).The area under the ROC curve was 0.917,0.919,0.928,0.953 respectively at 4,24,48,72 h after coronary arteriography and PCI.The sensitivity and specificity of urinary NGAL in early diagnosis of CIN were 92.10％ and 100.00％ respectively.Conclusion High atorvastatin dose treatment can reduce the occurrence of CIN.Urinary NGAL level can indicate the change of renal function earlier than serum creatinine level after PCI,and can thus be used as an early predictor of CIN.
