Association of NLRP3 gene polymorphism with hypertension and carotid atherosclerosis in patients of Xinjiang Kazakh nationality
10.3969/j.issn.1009-0126.2018.01.007
- VernacularTitle:核苷酸结合寡聚结构域样受体蛋白3基因多态性与哈萨克族高血压颈动脉粥样硬化的关系
- Author:
Xiuying MA
1
;
Yuanming ZHANG
;
Chen DAI
;
Mengru WANG
;
Xiaoya GUO
Author Information
1. 新疆医科大学第一附属医院心脏中心
- Keywords:
polymorphism,genetic;
hypertension;
carotid artery diseases;
atherosclerosis;
gene frequency;
interleukin-1 beta
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(1):24-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of NLRP3 gene polymorphism with primary hyper tension (PH) and carotid atherosclerosis (CA) in patients of Xinjiang Kazakh nationality.Methods Three hundred and fifty PH patients of Xinjiang Kazakh nationality were divided into CA group (n=150) and CA-free group (n=200) with 200 Xinjiang Kazakh nationality people undergoing physical examination served as a control group in this study.Their NLRP3 rs10754558 genotypes and alleles were detected using the Tapman probe method and their serum IL-1β level was measured by ELISA.Results The detection rate of rs10754558 genotypes and alleles was significantly higher in CA group than in control group (20.0％ vs 9.0％,43.0％ vs 34.8％,P＜0.05).No significant difference was found in NLRP3 gene types and G alleles between the two groups (P＞ 0.05).The serum IL-1β level was significantly higher in CA and CA-free groups than in control group (2.79±0.83 ng/L and 2.82±0.92 ng/L vs 2.21±0.91 ng/L,P＜0.05) and in GG gene type carriers of CA and CA-free groups than in those of control group (3.40±± 0.37 ng/L and 3.35±0.43 ng/L vs 2.21±0.90 ng/L,P＜0.05).Conclusion NLRP3 rs10754558 gene polymorphism is associated with genetic susceptibility to hypertension and carotid atherosclerosis in patients of Xinjiang Kazakh nationality.
