Effect of masked hypertension and white coat hypertension on vascular elasticity and endothelial function in elderly patients
10.3969/j.issn.1009-0126.2018.01.002
- VernacularTitle:老年隐匿性高血压及白大衣性高血压对血管弹性及内皮功能的影响
- Author:
Tiantian JI
1
;
Fang WEI
;
Juan WANG
;
Wenjing HU
;
Dandan DUAN
;
Shangwen SUN
;
Hua ZHANG
;
Qiang CHAI
;
Zhendong LIU
Author Information
1. 250200,济南大学山东省医学科学院医学与生命科学学院
- Keywords:
hypertension;
blood pressure monitoring,ambulatory;
endothelium,vascular
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2018;20(1):4-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of masked hypertension (MH) and white coat hypertension (WCH) on vascular elasticity and endothelial function in elderly patients.Methods Four hundred and eighty-seven elderly patients who underwent physical examination in our our hospital were divided into normotension group (n=128),WCH group (n=115),MH group (n=112) and hypertension group (n=132) according to their diagnostic office blood pressure and 24 h ambulatory blood pressure.The brachial artery FMD,serum NO and endothelin-1 (ET-1) levels,and cfPWV were measured.Results The FMD and serum NO level were significantly lower while the serum ET-1 level and cfPWV were significantly higher in WCH group,MH group and hypertension group than in normotension group (P＜0.05).The FMD and serum NO level were significantly higher while the serum ET-1 and cfPWV were significantly lower in WCH group and MH group than in hypertension group (P＜ 0.05).Multivariate linear stepwise regression analysis showed that WCH,MH and hypertension were the independent influencing factors for FMD,serum NO and ET-1 level and cfPWV with normotension used as reference after adjustment of confounding factors (P＜0.01).Conclusion MH and WCH are the risk factors for the decreased vascular elasticity and endothelial dysfunction in elderly patients.
