Progress on the resistance mechanism of Enterococcus to linezolid
10.3760/cma.j.issn.1674-2397.2018.01.013
- VernacularTitle:肠球菌对利奈唑胺耐药机制的研究进展
- Author:
Yaling LOU
1
;
Wei YU
;
Zhe WU
;
Yunqing QIU
Author Information
1. 浙江大学医学院附属第一医院感染病中心传染病诊治国家重点实验室
- Keywords:
Enterococcus;
Vancomycin-resistance;
Linezolid;
Drug resistance
- From:
Chinese Journal of Clinical Infectious Diseases
2018;11(1):66-70
- CountryChina
- Language:Chinese
-
Abstract:
Enterococcus is an opportunistic pathogen of nosocomial infection.In recent years, the resistance rate of Enterococcus to antimicrobial agents is increasing with the widespread use of antibiotics, even leading to the development of vancomycin-resistant Enterococcus(VRE).Linezolid is a synthetic oxazolidinone antibiotic, which less likely to generates the cross-resistance with other antimicrobial agents that inhibit bacterial protein synthesis,so it has been regarded as the last line of defense for VRE.However, since the linezolid has appeared on the market, the reports of linezolid-resistant Enterococcus have also emerged.This article reviews the resistance mechanisms of Enterococcus to linezolid in order to provide reference for resistance surveillance as well as the research and development of new antimicrobial agents.
