Efficacy of the traditional Chinese medicine NAOAN capsule for primary prevention of stroke in high-risk population
10.3760/cma.j.issn.1674?0815.2018.05.006
- VernacularTitle:中药脑安胶囊在社区脑卒中高危人群干预管理应用再评价
- Author:
Hongmei LIU
1
,
2
;
Bin JIANG
;
Jiuyi HUANG
;
Yunhai LIU
;
Zhen HONG
;
Li HE
;
Siyan ZHAN
;
Dongling SUN
;
Xiaojuan RU
;
Haixin SUN
;
Wenzhi WANG
Author Information
1. 100050 北京,首都医科大学北京市神经外科研究所
2. 100050 北京,全国脑血管病防治研究办公室
- Keywords:
Stroke;
Community medicine;
High-risk population;
NAOAN capsule;
Intervention management
- From:
Chinese Journal of Health Management
2018;12(5):415-419
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of the traditional Chinese medicine NAOAN capsule in primary prevention of stroke in high?risk populations. Methods A multicenter, randomized controlled study was performed in community setting, involving 1 088 individuals at high risk of stroke, with cerebrovascular function scores<75 and 10?year Framingham stroke risk ≥6%. Subjects were recruited in communities at Beijing, Shanghai, Changsha, and Chengdu communities, through resident committees or the village unit. A total of 559 subjects were randomized into a group treated with the NAOAN capsule, and 529 subjects in an aspirin treatment group. Follow?up was performed every 2 months for 2 years. At the mid?point and end of the intervention, we compared cerebrovascular function differences between the 2 groups. Results During the 2?year community trial, 531 subjects in the NAOAN capsule group and 465 in the aspirin group followed the protocol. Cerebrovascular function scores increased from 45.2±19.7 at baseline to 61.7±26.5 after the 2?year trial (t=－12.931, P<0.001) in the NAOAN capsule group, and from 47.2±18.9 at baseline to 53.7 ± 25.1 (t=－5.058, P<0.001) in the aspirin group; greater increases in cerebrovascular function scores were found in the NAOAN capsule group than that in the aspirin group (t=4.906, P<0.001). Conclusions Cerebrovascular function in individuals at high risk of stroke was improved by taking NAOAN capsule. Cerebrovascular function scores improved more with NAOAN capsules than with aspirin.
