Malignant Solitary Fibrous Tumor of the Pleura in Mediastinum.
- Author:
Yun Kyung KANG
;
Hyun Joo YOO
;
Ho Kee YUM
;
Hong Sup LEE
- Publication Type:Case Report
- Keywords:
Malignant solitary fibrous tumor;
Pleura;
Mediastinum;
CD-34;
Electron micro-scopy
- MeSH:
Collagen;
Epithelioid Cells;
Fibroblasts;
Hemorrhage;
Mediastinum;
Myofibroblasts;
Necrosis;
Peritoneum;
Pleura;
Solitary Fibrous Tumor, Pleural*;
Solitary Fibrous Tumors*;
Vimentin
- From:Korean Journal of Pathology
1997;31(4):351-356
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Solitary fibrous tumors (SFTs) most often involve the pleura and also may encompass the peritoneum and nonserosal sites. They occur as solitary encapsulated tumors and pursue a relatively benign clinical course. The usual criteria for malignancy are high cellularity, mitotic activity (more than 4 per 10 high-power fields), cellular pleomorphism, hemorrhage and necrosis as well as infiltrative growth. We report a case of malignant SFT of pleura who presented with an anterior mediastinal mass. Grossly, it was a 10x8x6.5 cm sized, encapsulated and well-demarcated, solid neoplasm with areas of extensive necrosis. Microscopically, parallel or haphazard arrangement of spindle cells with variable degrees of collagenous background were noted. Storiform fascicle formation, hemangiopericytoma-like pattern, and epithelioid cell clusters were often intermingled. Nodular areas with high cellularity and mitotic activity (> or =10/10 HPFs) were scattered throughout the neoplasm, however no definite cellular pleomorphism was encountered. Tumor cells were immunoreactive for vimentin and CD-34, which distinguished them from the mesothelial cells. Electron microscopically, they revealed fibroblastic and myofibroblastic differentiation.
