Production, quality control and micro PET analysis of novel solid-target based radionuclide 64 Cu
10.3760/cma.j.issn.2095-2848.2018.12.006
- VernacularTitle:新型固体靶核素64Cu的生产、质控及microPET显像
- Author:
Hua ZHU
1
;
Feng WANG
;
Teli LIU
;
Fei LIU
;
Qinghua XIE
;
Xiangxi MENG
;
Qiushi REN
;
Zhi YANG
Author Information
1. 100142,北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科、恶性肿瘤发病机制及转化研究教育部重点实验室
- Keywords:
Nickel;
Copper radioisotopes;
Positron-emission tomography;
Mice
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(12):797-800
- CountryChina
- Language:Chinese
-
Abstract:
Objective To briefly retrospect the production and quality control of 64 Cu(n = 9) in Department of Nuclear Medicine of Peking University Cancer Hospital in order to provide useful information for the further production and application of this novel radionuclide. Methods 64 Ni(p, n) 64 Cu nuclide re-action was used for the 64 Cu production. Firstly, a new electro-planting device for 64 Ni planting was de-signed. HM-20 cyclotron was applied to irradiate the slice for 5-8 h. 64 CuCl2 was purified, collected and in-jected into normal mice. MicroPET was conducted to monitor the metabolism in vivo. Results A new type of electro-planting device was designed and assembled. The enriched 64 Ni target showed smooth, even, dense surface and without obvious pits and cracks. High specific 64 Cu (1.3-4.1 GBq) can be collected after radio-chemical purification. 64 Cu was finally dissolved in 0.01 mol/ L HCl with high radionuclide purity (over 99.97％). MicroPET of 64 CuCl2 in normal mice showed that the radioactivity was mainly accumulated in the liver. Conclusion A new and real-time observable device for 64 Ni electro-plating has been designed and successfully used in the production of 64 Cu with high specific activity.
