Relationship between the semi-quantitative index of 99 Tcm-3PRGD2 SPECT/ CT imaging and clinical pathological features of breast cancer
10.3760/cma.j.issn.2095-2848.2018.12.003
- VernacularTitle:99Tcm-3PRGD2 SPECT/CT显像半定量参数与乳腺癌临床病理特征的关系
- Author:
Haiyan LIU
1
;
Wanting LI
;
Lijun QIN
;
Yali CUI
;
Jing NIU
;
Zhifang WU
;
Jing LIU
;
Guochen ZHANG
;
Yuan REN
;
Yongping CUI
;
Sijin LI
Author Information
1. 山西医科大学第一医院核医学科、山西省分子影像协同创新中心
- Keywords:
Breast neoplasms;
Tomography;
emission-computed;
single-photon;
Tomography;
X-ray computed;
Arg-Gly-AspFund program
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(12):786-789
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the tumor/ non-tumor (T/ NT) ratio during 99 Tcm-hydrazinon-icotinamide(HYNIC)-( poly-( ethylene glycol), PEG) 4-Glu( cyclo ( Arg-Gly-Asp-D-Phe-Lys ( PEG4 ))) 2 ( 99 Tcm-3PRGD2 ) SPECT/ CT imaging and clinical pathological features of breast cancer. Methods Forty-five female patients (age range: 39-76 (53.0±9.5) years) with suspected breast malignant nodules or mas-ses from October 2016 to June 2017 were prospectively enrolled. Patients underwent 99 Tcm-3PRGD2 SPECT/CT imaging before breast puncture and surgery. All subjects had pathological results, and estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2(HER-2), Ki-67 and mi-crovessel density ( MVD) were obtained by immunohistochemistry and fluorescence in situ hybridization(FISH). Two-sample t test and Kruskal-Wallis H test were used to analyze the data. Results Invasive duc-tal carcinoma was pathologically confirmed in 35 of 45 patients. There were 7 patients in stage Ⅰ, 11 pa-tients in stage ⅡA and 17 patients in stage ⅡB. The Luminal A subtype, Luminal B subtype, ERBB2+subtype, Basal-like subtype were found in 6, 9, 9 and 11 patients, respectively. The T/ NT ratio was signifi-cantly higher in the stageⅡB patients than that in stageⅠ+ⅡA patients (4.54±1.46 vs 3.32±1.72, t= -2.24, P<0.05). Patients with ERBB2+ subtype had higher T/ NT ratio compared to patients with Basal-like sub-type: 5.80(3.90, 6.70) vs 2.80(2.20,3.50), H= 11.06, χ2 = 15.31, both P<0.05. Besides, the T/ NT ra-tios in the HER-2 positive group and lymphatic metastasis group were significantly higher than those in the HER-2 negative group and group without lymph node metastasis (t values: -3.99, -2.51, both P<0.05). MVD of HER-2 positive group was higher than that of HER-2 negative group (t= 7.13, P<0.01). Conclu-sion The T/ NT ratio during 99 Tcm-3PRGD2 SPECT/ CT imaging has relations with TNM staging, lymph node infiltration and HER-2 in breast cancer.
