Lexiscan can open the blood-brain barrier temporarily and reversibly
10.3760/cma.j.issn.2095-2848.2018.11.007
- VernacularTitle:瑞加德松注射液可暂时可逆性开放血-脑屏障
- Author:
Cancan CHANG
1
;
Yang DUAN
;
Benqiang YANG
;
Jun ZHOU
;
Hongyi LI
;
Zhihua XU
;
Sen LIN
Author Information
1. 110016,沈阳军区总医院放射科
- Keywords:
Blood-brain barrier;
Adenosine A2 receptor agonists;
Magnetic resonance imaging;
Gadolinium DTPA;
Rabbits
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(11):741-744
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the opening level and optimal time window of the blood-brain barrier induced by adenosine A2 receptor agonist ( Lexiscan) via dynamic enhanced MRI. Methods Twen-ty New Zealand white rabbits were divided into experiment group ( group A, n=10) and control group ( group B, n=10) . Rabbits in group A were injected with Lexiscan and rabbits in group B were injected with physiological salt via ear vein, then the coronary scanning was performed. Contrast enhanced MRI was performed at different time points ( 5, 10, 15, 20 min, and then every 10 min, until 2 h) following the in-fusion of Gd-diethylene triamine pentaacetic acid (DTPA). The signal intensity (SI) of region of interest ( ROI) was measured and the percent enhancement of SI was calculated. Evens blue staining results in brain tissues were observed. Pair t test was used to analyze the data. Results The percent enhancement of SI in group A significantly increased to (40. 93±3.70)％ at 5 min, reached the maximum of (43.03±3.62)％ at 30 min, slowly decreased until 50 min, and got to a stable level at almost 80 min. At each time point, the per-cent enhancement of SI in group A was significantly higher than that in group B ( t values:6.88-20.28, all P<0. 05) . The staining was evident in group A. Conclusions Lexiscan can open blood-brain barrier tem-porarily and reversibly, and the optimal opening time window is 10-50 min post-injection.
