Clinical features and imaging analysis of SAPHO syndrome in 14 cases
10.3760/cma.j.issn.2095-2848.2018.10.003
- VernacularTitle:14例SAPHO综合征患者的临床特点与影像学分析
- Author:
Qingsong JIAO
1
;
Faquan JI
;
Anping JI
;
Ling BAI
;
Jie ZHANG
;
Ping HE
;
Minghua DU
Author Information
1. 210029,南京中医药大学附属医院核医学科
- Keywords:
Acquired hyperostosis syndrome;
Radionuclide imaging;
Tomography;
X-ray computed;
Technetium Tc 99m medronate
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(10):659-661
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the recognition of synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome by investigating its clinical features and imaging manifestations. Methods The data of 14 patients with SAPHO syndrome (8 males, 6 females, age range: 18-61 years) between January 2014 and January 2017 were retrospectively analyzed. The clinical features, the results of laboratory (erythrocyte sedimentation rate (ESR), C reaction protein (CRP), complement component 3 (C3) and component 4 (C4), human leukocyte antigen (HLA)-B27) tests, pathology and imaging examinations (CT and whole-body bone im-aging) were collected. Results SAPHO syndrome was mainly characterized by skin damage and bone joint damage. The main manifestations of skin lesions were pustules, desquamation and erythema. Those of bone and joint injury were sternocostoclavicular hyperostosis, stiff spinal hyperostosis, peripheral arthritis, and sacroiliitis. There were 5 with fasting ESR, 5 with abnormal CRP, 3 with abnormal C3, and 1 with abnormal C4 among 14 patients. HLA-B27 was negative in all patients. Whole-body bone imaging revealed that 14 pa-tients had abnormal radioactivity, mainly involving the anterior chest wall, spine, pelvis and long bone. Chest CT manifestations of the patients were the destruction of joint bone, the fusion of the hypertrophy and the narrowing of the joint space. Symmetric lesions accounted for the majority. Pathology examination showed non-specific inflammation in 9 patients. Conclusions SAPHO syndrome is a disease characterized by skin, bone and joint abnormalities. Whole-body bone imaging can find systemic bone damage in early stage, and CT can detect bone changes and soft tissue lesions.
