Characteristics of cerebral glucose metabolism in patients with corticobasal degeneration
10.3760/cma.j.issn.2095-2848.2018.10.002
- VernacularTitle:皮质基底节变性患者脑部葡萄糖代谢特征分析
- Author:
Qian XU
1
;
Ping WU
;
Chengfeng JIANG
;
Jingjie GE
;
Zhengwei ZHANG
;
Qihao GUO
;
Jianjun WU
;
Yihui GUAN
;
Chuantao ZUO
Author Information
1. 复旦大学附属华山医院 PET 中心
- Keywords:
Cerebral cortex;
Basal ganglia diseases;
Nerve degeneration;
Positron-emission tomography;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(10):654-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify abnormal cerebral glucose metabolism characteristics in patients with corticobasal degeneration (CBD) using 18 F-fluorodeoxyglucose (FDG) PET imaging. Methods From January 2014 to January 2017, resting-state brain 18 F-FDG PET imaging was performed in 10 CBD patients (5 males, 5 females; average age: (63.4±6.2) years) and 20 age-matched healthy subjects (8 males, 12 female; average age: (63.6±6.2) years). Voxel-based statistical parametric mapping (SPM) was used to analyze images to obtain the CBD-related brain metabolic characteristics. The regional cerebral metabolic rate of glucose (rCMRglc) was compared between 2 groups by two-sample t test. Results Compared with healthy controls, CBD group demonstrated asymmetrically decreased glucose metabolism mainly in the cere-bral hemisphere opposite to the more clinically affected body side, including the superior, middle and inferi-or frontal gyrus, the precentral gyrus, the superior and inferior parietal lobule, the angular gyrus, the supra-marginal gyrus, the precuneus, the middle occipital gyrus, the middle and inferior temporal gyrus, Heschl gyrus, the fusiform gyrus, the insula and the thalamus. And relatively increased glucose metabolism was present in ipsilateral precentral and postcentral gyrus, hippocampus, insula and putamen, bilateral cerebel-lum, paracentral lobules and pontine. The rCMRglc in those regions was significantly different between CBD patients and healthy controls (t values: 4.236-9.044, all P<0.01). Conclusion The asymmetric cerebral glucose metabolism features in CBD based on 18 F-FDG PET imaging contribute to the differential diagnosis between CBD patients and healthy subjects.
