Efficacy of 99Tc-MDP combined with calcium and vitamin D3 for treating secondary osteoporosis in patients with rheumatoid arthritis
10.3760/cma.j.issn.2095-2848.2018.09.008
- VernacularTitle:云克联合钙剂和维生素D3治疗类风湿关节炎骨质疏松的疗效观察
- Author:
He HUANG
1
,
2
;
Yue CHEN
Author Information
1. 646000泸州,西南医科大学附属医院核医学科
2. 泸州市人民医院核医学科 646000
- Keywords:
Arthritis,rheumatoid;
Osteoporosis;
Cholecalciferol;
Technetium Tc 99m medronate;
Treatment outcome
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(9):615-618
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of 99Tc-methylene diphosphonate (MDP) combined with calcium and vitamin D3 in the treatment of rheumatoid arthritis (RA) and secondary osteoporosis.Methods Fifty patients (19 males,31 females,average age:(56.21±18.32) years) with RA and secondary osteoporosis from January 2015 to December 2016 were selected as observation group.All of them were treated with 99Tc-MDP,calcium and vitamin D3.Another 39 patients with RA and secondary osteoporosis were randomly selected as control group,including 16 males and 23 females (average age:(60.37±12.56) years),and all were treated with methotrexate,calcium and vitamin D3.Curative effects before and after (3,6,12 months) the treatment were observed and compared.Two-sample t test was used for data analysis.Results Both of the 2 groups showed good response,and there was no statistical significance in improvement of morning stiffness,reducing joint tenderness and swelling (t values:0.3-0.6,all P＞0.05).The bone mineral density (BMD) of L2-L4 vertebral bodies and femoral neck were (0.64±0.05) and (0.59±0.06) g/cm2 6 months after treatment,and were (0.81±0.04) and (0.79±0.06) g/cm2 12 months after treatment in the observation group,which were all higher than those in the control group ((0.51±0.04),(0.50±0.05),(0.59±0.03),(0.52±0.05) g/cm2;t values:8.3-9.9,all P＜0.05).Conclusion 99TcMDP combined with calcium and vitamin D3 for RA and RA osteoporosis may achieve good curative effect.
