Role of nicotinic acetylcholine receptors in vascular cognitive impairment

VernacularTitle:烟碱型乙酰胆碱受体在血管性认知功能障碍中的作用
Author: Tingting HAN ¹ ; Yafu YIN
Author Information

1. 中国医科大学附属第一医院核医学科
Keywords: Cognition disorders; Dementia,vascular; Receptors,nicotinic; Trends
From: Chinese Journal of Nuclear Medicine and Molecular Imaging 2018;38(6):436-440
CountryChina
Language:Chinese
Abstract: Nicotinic acetylcholine receptors (nAChRs) play an important role in cognitive function.Vascular cognitive impairment (VCI) seriously affects the health and quality of life.Early diagnosis and timely effective intervention of VCI may delay or even prevent the occurrence of dementia.The development of nAChRs agents and molecular imaging,such as PET/CT or PET/MR,may promote research on the early diagnosis and treatment of VCI.This review summarizes the pathogenesis of VCI,the relationship between nAChRs and VCI,the progress on nAChRs receptor imaging,and the treatment of VCI.