Optimization of SPECT/CT scan schemes in localizing preoperative parathyroid lesions
10.3760/cma.j.issn.2095-2848.2018.05.004
- VernacularTitle:SPECT/CT对甲状旁腺功能亢进症病灶术前定位扫描方案的优化
- Author:
Qian HUA
1
;
Lin CHAO
;
Jianming NI
;
Yurui XU
;
Yanjun ZHUO
;
Ping TANG
;
Shiqin WANG
Author Information
1. 214002,南京医科大学附属无锡第二医院核医学科
- Keywords:
Hyperparathyroidism;
Diagnosis;
Tomography,emission-computed,single-photon;
Tomography,X-ray computed;
Technetium 99m sestamibi
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(5):320-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the diagnostic efficiencies of different scanning schemes of dualphase 99Tcm-methoxyisobutylisonitrile (MIBI) planar imaging with or without SPECT/CT in the preoperative localization of parathyroid lesions.Methods Forty-two patients (20 males,22 females;average age (53.1 ± 14.8) years) with primary or secondary hyperparathyroidism who underwent parathyroidectomy from June 2011 to June 2016 were analyzed retrospectively.All patients underwent dual-phase 99Tcm-MIBI planar scan and dual-phase SPECT/CT scan.The images were collected according to the following 4 procedures:dualphase planar imaging (S1),dual-phase planar imaging+early-phase SPECT/CT (S2),dual-phase planar imaging+delayed-phase SPECT/CT (S3),dual-phase planar imaging+dual-phase SPECT/CT (S4).Pathological results were considered as the gold standard.A total of 168 parathyroid glands in 42 patients were evaluated by the 4 imaging procedures respectively.The diagnostic efficiencies were calculated and compared by x2 test.Results Seventy-eight abnormal parathyroid lesions were found.The diagnostic sensitivities of S1,S2,S3,S4 were 66.7％ (52/78),89.7％(70/78),69.2％(54/78),89.7％(70/78),and the accuracies were 78.6％ (132/168),94.0％ (158/168),85.1％ (143/168),94.0％ (158/168),respectively.The diagnostic accuracies of S2 and S4 were significantly higher than those of S1 and S3 (x2 values:17.027 and 7.176,both P＜0.01).Condusions The dual-phase planar imaging together with early-phase and dualphase SPECT/CT imaging have high diagnostic efficiencies in the preoperative localization of parathyroid lesions.Considering reducing radiation dose and examine time,the dual-phase planar imaging together with early-phase SPECT/CT is a better choice.
