Analysis of hypermetabolic lesions on 18F-FDG PET/CT scan in pediatric patients with epilepsy
10.3760/cma.j.issn.2095-2848.2018.04.002
- VernacularTitle:小儿癫(癎)18F-FDG PET/CT高代谢灶的判读及分析
- Author:
Zhenghao TONG
1
;
Yan FAN
;
Rongfu WANG
;
Lixin CAI
;
Xiaoyan LIU
;
Jianhua ZHANG
;
Xuchu ZHANG
;
Zhanli FU
;
Meng LIU
Author Information
1. 100034,北京大学第一医院核医学科
- Keywords:
Epilepsy;
Child;
Positron-emission tomography;
Tomography,X-ray computed;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(4):234-237
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of metabolic foci on 18F-fluorodeoxyglucose (FDG) PET/CT scan in pediatric patients with epilepsy.Methods Twenty-three pediatric patients (15 males,8 females,age range:0.5-13.3 years) with epilepsy were retrospectively reviewed from March 2014 to December 2016.All patients underwent 18F-FDG PET/CT and metabolic foci were found.The visual method and semi-quantitative analysis were used to analyze images.Fourteen of them underwent surgery and were followed up for 3-24 months.Results Glucose hypermetabolism were observed most frequently in the frontal and parietal lobes,with or without surrounding/remote hypometabolism.On the day of PET/CT imaging,8 patients had no seizures,14 patients had seizures,and 1 patient was uncertain.The sites of resection were consistent with the regions of hypermetabolism in 9 patients,among whom the pathological results showed 8 cortical malformations and 1 Rasmussen's syndrome.Follow-up results for the above 9 patients showed that there was 7 Engel class Ⅰ patients and 2 Engel class Ⅲ patients.Conclusion The hypermetabolism may mostly appear in the frontal and parietal lobes of pediatric patients with epilepsy,and malformations of cortical development seem to be the most common pathology results.
