125I seeds implantation in patients with castration resistant prostate cancer
10.3760/cma.j.issn.2095-2848.2018.03.010
- VernacularTitle:125I粒子前列腺植入近距离放射治疗去形抵抗性前列腺癌
- Author:
Yang LUAN
1
;
Xuefei DING
;
Xiao GU
;
Tianbao HUANG
;
Shengming LU
;
Huazhi TAO
Author Information
1. 225001,扬州大学临床医学院、江苏省苏北人民医院泌尿外科
- Keywords:
Prostatic neoplasms;
Brachytherapy;
Iodine radioisotopes
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(3):191-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of brachytherapy with 125I seeds implantation in patients with castration resistant prostate cancer (CRPC).Methods Twenty-eight patients with CRPC from February 2010 to December 2015 in Northern Jiangsu People's Hospital were analyzed retrospectively.Patients were divided into 2 groups according to different treatment methods.Control group (n =13) received endocrine therapy,and study group (n =15) underwent brachytherapy combined with endocrine therapy.The progression was defined as posttreatment prostate specific antigen (PSA) ≥ 125％ PSA of baseline level.PSA-progression-free survival (PFS),overall survival (OS) and quality of life (physical functioning,social functioning,general health,general physical discomfort,urinary symptoms and treatment-related symptoms) of 2 groups were compared using Kaplan-Meier analysis and log-rank test.Results The median PSA-PFS and OS of study group were 29(24,37) months and 37(32,50) months respectively,both of them were longer than those of control group (13(7,21) months,19(14,23) months;x2 =13.300,19.362,both P＜0.01).Comparing with control group,the physical functioning,social functioning,general health and general physical discomfort of study group were improved.Conclusion Brachytherapy can effectively prolong the survival of CRPC patients and improve the patients' life quality.
